Testosterone replacement therapy (TRT) has become a common treatment for men who have a blood level of testosterone lower than 300 ng/dl with symptoms of testosterone deficiency. While TRT has some very positive benefits, a new study found why men on TRT are now finding themselves diagnosed with prostate hyperplasia. 

Prostate hyperplasia can lead to frequent urination in some men. The prostate, which is at the base of the bladder, is rich in testosterone receptors and can enlarge when men are on TRT thus causing urinary frequency and urgency.

A recent article published in the Urology Journal (edition 196) highlights that men on testosterone replacement therapy are more likely to be diagnosed with prostate hyperplasia (enlargement) after 2.5 years of TRT treatment.

The enlarged prostate can be treated with medical therapy or surgical therapy, but this and numerous studies show that TRT treatment does not result in increased risk of intervention compared to men not receiving TRT therapy.

If you are bothered by your urination, make an appointment at The Y Factor for evaluation and treatment. The Y Factor can also help you explore natural methods of testosterone production backed by the latest research and guided by Dr. Russel Williams. 

Citation: J Fendereski et Al; urology 196,2025 p325

Russel H. Williams, MD

Dr. Russel H. Williams is the founder, CEO and CMO of The Y Factor and brings more than 20 years of experience. Dr. Williams earned his Medical Degree at the University of Texas at Dallas Southwestern Medical Center, where he graduated at the top of his class. He completed his urology residency at Baylor College of Medicine in Houston, then completed a male reproductive medicine and microsurgery visiting fellowship at the New York-Presbyterian/Weill Cornell Medical Center in Manhattan, New York. Dr. Williams is an active member of the American Urological Association, American Society for Reproductive Medicine, and peers recognize him as one of only a handful of Reproductive Urologists focusing on men’s urological wellness & fertility.