MANday: Improving sperm DNA to improve fertilization rates in assisted reproduction
Assistant reproduction is defined as using advanced fertility techniques such as intrauterine insemination or in vitro fertilization to enhance fertilization rates. The success of these techniques relies on the ability to place the sperm or the sperm DNA in proximity to the unfertilized egg.
These techniques have provided fertility success for couples with significantly abnormal semen analysis with low count, low motility or very few sperm available through sperm extraction.
With the newfound success of these techniques also comes the realization that many couples are still not able to conceive after assisted reproduction.
Sperm DNA and sperm DNA quality have been suspected as leading to fertilization failure with assisted reproduction. Several new studies have looked at the sperm preparation technique to determine if better quality sperm can be made available for fertilization.
Density centrifugation, swim up separation, and microfluids sorting are all sperm preparation techniques being investigated to increase fertilization rates.
Excessive agitation of the sperm during preparation has been found to create free oxygen radicals and sperm DNA damage. This has limited the success of some sperm preparation techniques.
At The Y Factor we see many couples who have sperm with abnormal sperm DNA. Our approach is to evaluate the man to reverse all conditions that can cause decreased sperm quality and decreased sperm DNA. This can be helpful for couples trying to conceive naturally or those that require further assistance with advanced reproductive techniques.
Reversible conditions causing decreased sperm DNA quality include infections, varicoceles, hormone imbalance, hydroceles, lifestyle choices,and certain medications. Through advanced sperm DNA testing, we are able to determine if a man has decreased sperm quality and also monitor his response to treatment.
The Y Factor is a premier medical facility for men with fertility problems. We have locations across the greater Houston area and appointments are available right now to see our specialists.
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