Klinefelter Syndrome is a rare condition affecting guys resulting in zero sperm count. They will have small testes and low testosterone levels detected in early years by their pediatrician or by a physician during a high school physical. 

These guys might be tempted to go on testosterone therapy treatment by some well intentioned physician or testosterone therapy center, but they’re future fertility is often forgotten about. If they want future fertility, a new study in the American Urology Association’s The Journal of Urology showed that: 

-20-30 years old have the best chance of fertility but this gets “wiped out if they go on T therapy“. 

-30-40 year olds have a lower chance of finding sperm for fertility. 

-40-older it is hard to find sperm and fertility requires donor sperm. 

Men with Klinefelter Syndrome have to be diagnosed with a blood test, but early suspicion occurs with an examination. Klinefelter men need to see a reproductive urologist to obtain fertility because they will have a zero sperm count. Klinefelter men would have the highest chance at fertility if they had their children thru ages 25-35 AND avoided any testosterone treatment. 

If they have not met the “right person” to have children with then they should consider having sperm removed from their testicles and frozen because after age 40 it is almost zero that sperm will be found! If men have a strong need to go on testosterone therapy (performance issues and or bone health) then they should consider having their sperm frozen.

Russel H. Williams, MD

Dr. Russel H. Williams is the founder, CEO and CMO of The Y Factor and brings more than 20 years of experience. Dr. Williams earned his Medical Degree at the University of Texas at Dallas Southwestern Medical Center, where he graduated at the top of his class. He completed his urology residency at Baylor College of Medicine in Houston, then completed a male reproductive medicine and microsurgery visiting fellowship at the New York-Presbyterian/Weill Cornell Medical Center in Manhattan, New York. Dr. Williams is an active member of the American Urological Association, American Society for Reproductive Medicine, and peers recognize him as one of only a handful of Reproductive Urologists focusing on men’s urological wellness & fertility.